Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis
نویسندگان
چکیده
منابع مشابه
Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.
UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and even to extrahepatic ones. Such versatility is the result of its multiple mechanisms of action. UDCA stabilizes plasma membranes against cytolysis by tensioactive bile acids accumulated in cholestasis. UDCA also halts ...
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The present study was designed to examine the hepatoprotective effects of curcumin (CMN), resveratrol (RSV) and ursodeoxycholic acid (UDCA) against ethinylestradiol and chlorpromazine -induced intrahepatic cholestasis. Ethinylestradiol (EE) and chlorpromazine HCl (CPZ) were administered orally once daily simultaneously with the tested compounds for one week. At the end of the experimentation pe...
متن کاملIntrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid.
Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by generalized pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. The most predictive and accurate markers for diagnosis and follow-up of ICP are increased total bile acid levels (above 11,0 micromol/L), enhanced cholic acid percentage (above 42%) and decreased glycine/taurine...
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Ursodeoxycholic acid (UDCA) is a steroid bile acid approved for primary biliary cirrhosis (PBC). UDCA is reported to have "hepato-protective properties". Yet, UDCA has "unanticipated" toxicity, pronounced by more than double number of deaths, and eligibility for liver transplantation compared to the control group in 28 mg/kg/day in primary sclerosing cholangitis, necessitating trial halt in Nor...
متن کاملEfficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy.
UNLABELLED Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHOD...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2019
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2019.06.009